CASE NO: 045
OBJECT: | Dispersion of isotretinoin in oil/gelatin dosage form. | PROBLEM: | Pre-disperse 100 micron crystals of isotretinoin prior to final fine grinding and incorporation into dosage form. | RESULTS: | Reversible homogenizing mixer is able to effectively prepare a pre-dispersion that optimizes the subsequent processing with a liquid jet micronizer. | AB MIXER: | Model CJ-4C Reversible Homogenizer |
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